The Knowing Gene

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But powerful techniques are now available, and one million SNPs from an individual can easily be genotyped, while costs for this whole genome variation analysis are decreasing fast.

The Knowing Gene by Robert Lange - FictionDB

These are called genome-wide association studies GWAS with case-control designs and have been broadly employed to capture genetic information on complex diseases. In this case candidate genes are coming out after this entire genome screening. Also, genetic and epidemiology are developing novel and refined statistical tools to screen these results. Nevertheless, the great challenge is to clearly define a specific and well characterized phenotype in order to screen the genetic variation associated with it.

The Knowing Gene

A single feature that can be tested using case-control designs can depict the associated allele. Obviously, it is not always easy to define a well characterized phenotype since the complexity of the feature may be cryptic and could not be broken down; besides, the genotype-phenotype relationship itself may be more complex, involving other genetic and non-genetic factors that add up to a set of sufficient causes.

The Knowing Gene

Nevertheless, some examples can be used to illustrate the current applications of genomic research in health, where knowing specific genotypes help predict and interfere with the phenotype. In this case, HCV patients were grouped as to whether or not they exhibited a sustained virological response SVR , which means patients were able to clear HCV six months after the interruption of treatment. The complete genome was searched for all polymorphisms in both groups and elegant statistical analyses were applied.

Individuals carrying the TT genotype at the rs SNP were shown to be poor responders and results showed impressive high odds-ratio values in different ethnicities 2. To test these hypotheses more specifically, several case-control studies in dozens of different populations were conducted and eventually corroborated the association of IL28B SNPs and SVR. One important genetic premise was maintained when evaluating this findings: Then, it was found out that the IL28B , a type III interferon, played a crucial role in activating antiviral responses.

The other astonishing genome finding was the association of specific polymorphisms with very low LDL low density lipoprotein levels. As a consequence, these SNPs have also been associated with decreased risk of coronary heart disease. It has been reported that rare polymorphisms in two women showed lower levels of LDL, although no clinical conditions were found. Different biopharmas are now testing this approach as a highly specific treatment based on the discovery of a genetic polymorphism. Want to Read Currently Reading Read.

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Refresh and try again. Open Preview See a Problem? Thanks for telling us about the problem. Return to Book Page. The Knowing Gene really liked it 4. One might think that being able to know the truth about anything would be a wonderful gift to have. Unfortunately, as Christian Faraday discovered--it wasn't. A strong psychic ability suddenly thrust upon him by an unusual incident at 14, feet, Christian thinks he is being a good citizen in helping the FBI solve a series of high profile disappearances. Unfortunately, he One might think that being able to know the truth about anything would be a wonderful gift to have.

Unfortunately, he proves so valuable that he finds the peaceful life he shares with his daughter quickly transformed. A series fast-paced adventures quickly ensues as various governmental and criminal organizations vie to monopolize his newly acquired ability--and not altogether for altruistic purposes. As Christian and his daughter manage to elude the authorities, a beautiful CIA agent relentlessly pursues him, only to find herself becoming a significant part his adventure.

Laced throughout with surprising action, subtle humor, and simmering romance, The Knowing Gene is a fast, easy, and entertaining read for all ages. As enjoyable, absorbing, and entertaining as it can be, it is NOT, however, going to change your life. If you're the kind of reader that routinely goes through over two thousand pages of classics in a couple of weeks, you probably will not enjoy this book and I encourage you not to read it.

On the other hand, if you're looking for an entertaining escape, you'll probably thoroughly enjoy 'The Knowing Gene'. Paperback , pages. To see what your friends thought of this book, please sign up.


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To ask other readers questions about The Knowing Gene , please sign up. Lists with This Book. This book is not yet featured on Listopia. Jan 31, Sue rated it it was amazing. I read a lot and this book was something different for me. A satisfying read that had me hooked and was hard to put down.

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The premise was different and interesting and the main character, Christian Faraday is one of those charming, intelligent, quirky men that you just naturally want to cheer on as he struggles with some new found knowledge and paranormal abilities without losing his integrity and sense of fair play. This book had enough twists to keep me guessing and turning the pages!

If you l I read a lot and this book was something different for me. If you like action and adventure books with a touch of romance something other than your average, run-of-the-mill shoot 'em ups, I recommend getting this book! Sep 23, Connie rated it it was amazing. I really enjoyed this book. It was one of those books you can't wait to have time to pick it back up again and read more.

I really fell in love with the characters. The book had a wonderful story line. It was easy to read and didn't require me to get out a dictionary to look up the meaning to the words. Take the book to the beach, cuddle up on the couch with it or where-ever you like to read. I can't wait f I really enjoyed this book. I can't wait for the sequel to come out! Sep 22, Leigh Blevins rated it it was amazing. Thoroughly enjoyed this wonderful book! Finished it in two days. I could not put this book down.. View on the Mobile Site.


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  7. One might think that being able to know the truth about anything would be a wonderful gift to have. Unfortunately, as Christian Faraday discovered--it wasn't. A strong psychic ability suddenly thrust upon him by an unusual incident at 14, feet, Christian thinks he is being a good citizen in helping the FBI solve a series of high profile disappearances.