Tissue Repair, Contraction and the Myofibroblast (Biotechnology Intelligence Unit)

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Generate a file for use with external citation management software. Abstract After the first description of the myofibroblast in granulation tissue of an open wound by means of electron microscopy, as an intermediate cell between the fibroblast and the smooth muscle cell, the myofibroblast has been identified both in normal tissues, particularly in locations where there is a necessity of mechanical force development, and in pathological tissues, in relation with hypertrophic scarring, fibromatoses and fibrocontractive diseases as well as in the stroma reaction to epithelial tumors. Supplemental Content Full text links.

Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis. A combined immunohistochemical and in situ hybridization study. J Hand Surg Am. Progressive lung cell reactions and extracellular matrix production after a brief exposure to asbestos. The roles of the myofibroblast in idiopathic pulmonary fibrosis. Ultrastructural and immunohistochemical features of sites of active extracellular matrix synthesis. Extracellular matrix composition and gene expression in collagenous colitis. Myofibroblasts and extracellular matrix glycoproteins in palmar fibromatosis.

Adult human colonic subepithelial myofibroblasts express extracellular matrix proteins and cyclooxygenase-1 and —2. Up-regulation of extracellular matrix proteoglycans and collagen type I in human crescentic glomerulonephritis. Abnormal mucosal extracellular matrix deposition is associated with increased TGF-beta receptor-expressing mesenchymal cells in a mouse model of colitis. Microstructural characteristics of extracellular matrix produced by stromal fibroblasts. Rho-associated kinases are crucial for myofibroblast differentiation and production of extracellular matrix in scleroderma fibroblasts.

Differences in transcriptional patterns of extracellular matrix, inflammatory, and myogenic regulatory genes in myofibroblasts, fibroblasts, and muscle precursor cells isolated from old male rat skeletal muscle using a novel cell isolation procedure. Diminished type III collagen promotes myofibroblast differentiation and increases scar deposition in cutaneous wound healing. Myofibroblastic stromal reaction in retracted scirrhous carcinoma of the breast.

Myofibroblastic stromal reaction in carcinoma of the breast: Increased content of type V collagen in desmoplasia of human breast carcinoma.

Tissue repair, contraction, and the myofibroblast. - PubMed - NCBI

Cell-mediated immunity to collagen V in lung transplant recipients: J Heart Lung Transplant. Type V collagen modulates alloantigen-induced pathology and immunology in the lung. Immunohistochemical localization of collagen types I and VI in human skin wounds. Int J Legal Med. Collagen VI in the extracellular matrix of normal and failing human myocardium.

Expression of collagen VI alpha5 and alpha6 chains in human muscle and in Duchenne muscular dystrophy-related muscle fibrosis. Increased expression of type VI collagen in lung fibrosis. Immunohistochemical localization of collagen VI in arthrofibrosis. Arch Orthop Trauma Surg. Extracellular matrix regulates expression of the TGF-beta 1 gene. New insights into form and function of fibronectin splice variants. Regulation of the fibronectin EDA exon alternative splicing. Transforming growth factor-beta regulates the splicing pattern of fibronectin messenger RNA precursor.

The fibronectin domain ED-A is crucial for myofibroblastic phenotype induction by transforming growth factor-beta1. Heparin-II domain of fibronectin is a vascular endothelial growth factor-binding domain: Fibronectin binds and enhances the activity of bone morphogenetic protein 1. Novel hepatocyte growth factor HGF binding domains on fibronectin and vitronectin coordinate a distinct and amplified Met-integrin induced signalling pathway in endothelial cells.

Antiangiogenic properties of fibstatin, an extracellular FGFbinding polypeptide. PDGF-A interactions with fibronectin reveal a critical role for heparan sulfate in directed cell migration during Xenopus gastrulation. Shape of tropoelastin, the highly extensible protein that controls human tissue elasticity.

Molecular biology and pathology of human elastin. Developmental regulation of elastin production. Elastin-like protein matrix reinforced with collagen microfibers for soft tissue repair. Cross-linked open-pore elastic hydrogels based on tropoelastin, elastin and high pressure CO 2. Venkataraman L, Ramamurthi A. Induced elastic matrix deposition within three-dimensional collagen scaffolds. Tissue Eng Part A. Restoring elastin with microRNA Regulation of elastin gene expression. Ann N Y Acad Sci.


Positive transcriptional regulatory element located within exon 1 of elastin gene. Upregulation of elastin expression in constrictive bronchiolitis obliterans. New insights into elastic fiber assembly.

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Ramirez F, Rifkin DB. Curr Opin Cell Biol. Ramirez F, Sakai LY. Biogenesis and function of fibrillin assemblies. Ramirez F, Dietz HC.

Stages of Wound Healing - Stage 3: Proliferation Granulation

Curr Opin Genet Dev. Extracellular microfibrils are increased in localized and systemic scleroderma skin. Avvedimento EV, Gabrielli A. Stiff and tight skin: Marfan-like skeletal phenotype in the tight skin Tsk mouse. Expression of isoforms and splice variants of the latent transforming growth factor beta binding protein LTBP in cultured human liver myofibroblasts. Fibronectin regulates latent transforming growth factor-beta TGF beta by controlling matrix assembly of latent TGF beta-binding protein Making sense of latent TGFbeta activation. Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts.

Serini G, Gabbiani G. Modulation of alpha-smooth muscle actin expression in fibroblasts by transforming growth factor-beta isoforms: Perturbation of transforming growth factor TGF -beta1 association with latent TGF-beta binding protein yields inflammation and tumors. Todorovic V, Rifkin DB. LTBPs, more than just an escort service. The role of proteases in transforming growth factor-beta activation. Int J Biochem Cell Biol. Wipff PJ, Hinz B.

Integrins and the activation of latent transforming growth factor beta1 — an intimate relationship.

The myofibroblast matrix: implications for tissue repair and fibrosis

Eur J Cell Biol. J Cell Commun Signal. Thrombospondin-1 is a major activator of TGF-beta1 in vivo. Matricellular proteins in cardiac adaptation and disease. Individual domains of connective tissue growth factor regulate fibroblast proliferation and myofibroblast differentiation. SPARC regulates collagen interaction with cardiac fibroblast cell surfaces.

Kos K, Wilding JP. Osteopontin expression is required for myofibroblast differentiation. Cardiac extracellular matrix remodeling: SPARC mediates early extracellular matrix remodeling following myocardial infarction. Molecular mechanisms linking wound inflammation and fibrosis: J Mol Cell Cardiol. Thrombospondin1 in tissue repair and fibrosis: Wnt-induced secreted protein-1 is a prohypertrophic and profibrotic growth factor. Mechanical stretch induces epithelial—mesenchymal transition in alveolar epithelia via hyaluronan activation of innate immunity.

Proposal for a unified CCN nomenclature. Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets. Nature Rev Drug Discov. CTGF and chronic kidney fibrosis. Connective tissue growth factor: Cytokine Growth Factor Rev. A polymorphism in the CTGF promoter region associated with systemic sclerosis.

N Engl J Med. Endothelin is a downstream mediator of profibrotic responses to transforming growth factor beta in human lung fibroblasts. Matrix control of scarring. Cell Mol Life Sci. Tenascin-C regulates recruitment of myofibroblasts during tissue repair after myocardial injury. Chiquet-Ehrismann R, Chiquet M. Tenascin-C deficiency attenuates TGF-ss-mediated fibrosis following murine lung injury.

Deficiency of tenascin-C attenuates liver fibrosis in immune-mediated chronic hepatitis in mice. Tenascin-X deficiency mimics Ehlers—Danlos syndrome in mice through alteration of collagen deposition. Tenascin-X deficiency is associated with Ehlers—Danlos syndrome. Wound healing in tenascin-X deficient mice suggests that tenascin-X is involved in matrix maturation rather than matrix deposition.

Potential role for heparan sulfate proteoglycans in regulation of transforming growth factor-beta TGF-beta by modulating assembly of latent TGF-beta-binding protein Biomarkers of hepatic fibrosis, fibrogenesis and genetic pre-disposition pending between fiction and reality. J Cell Mol Med. Modulation of TGFbeta1-dependent myofibroblast differentiation by hyaluronan. Age-related changes in pericellular hyaluronan organization leads to impaired dermal fibroblast to myofibroblast differentiation.

Hyaluronan attenuates transforming growth factor-beta1-mediated signaling in renal proximal tubular epithelial cells. Hyaluronan stabilizes focal adhesions, filopodia, and the proliferative phenotype in esophageal squamous carcinoma cells. Alpha-smooth muscle actin is crucial for focal adhesion maturation in myofibroblasts. Severe lung fibrosis requires an invasive fibroblast phenotype regulated by hyaluronan and CD Molecular and cellular mechanisms of syndecans in tissue injury and inflammation. Oxidative stress, extracellular matrix targets, and idiopathic pulmonary fibrosis.

Free Radic Biol Med. Oxidative stress alters syndecan-1 distribution in lungs with pulmonary fibrosis. Shedding of syndecan-1 and-4 ectodomains is regulated by multiple signaling pathways and mediated by a TIMPsensitive metalloproteinase. The Vaccine Race Meredith Wadman. Gene Machine Venki Ramakrishnan. Mast Cells David B. Single Molecule Techniques Taekjip Ha. Essential Cell Biology Dennis Bray.

Tissue Repair, Contraction and the Myofibroblast

Enjoy Your Cells Frances R. Introduction to Biomaterials Gopinath Mani. The Machinery of Life David S. Molecular Cell Biology Matthew P. I of the Vortex Rodolfo R. Pain-Free Biochemistry Paul C. Cellular and Molecular Neurophysiology Constance Hammond. Cells and Cell Function Carol Ballard.

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